Disorders related to anxiety are the most common mental health disorder in the United States. Based on a study conducted by the Anxiety and Depression Association of America, around 40 million adults suffer from anxiety disorders in the U.S.
The Centers for Disease Control and Prevention (CDC) warned that the ongoing global pandemic might drive these numbers up. A new disease without a known cure is overwhelming and might cause strong emotions in children and adults.
Health protocols such as social distancing, decreased communal interactions, and self-isolations can make people feel lonely. These can result in a feeling of isolation which bolters feelings of anxiety.
Research these past few years suggests that Cannabidiol (CBD) might help relieve anxiety. One study showed CBD as a therapeutic alternative for patients suffering from post-traumatic stress disorder (PTSD).
Due to the growing demands for CBD products, the market is now saturated with products that promise great results in treating anxiety. All of them are similar and it is difficult to choose which CBD product has an edge over the other.
We’ve taken a closer look at the CBD products available in the market to help you determine which products deliver results and not just empty promises.
Here’s an in-depth look at the Best CBD Oils for Anxiety in 2020
Important CBD Terms to Remember:
- Broad-spectrum CBD has a myriad of active CBD compounds without THC or just minute traces of it.
- Full-spectrum CBD contains the most strains of active cannabinoids. It has less than 0.3 percent of THC content and is non-psychoactive.
- CBD Isolate is CBD in its purest form.
- Tetrahydrocannabinol (THC) is an active chemical found in cannabis. THC is the chemical that induces psychological effects.
- Terpenes are organic aromatic compounds produced by plants and some insects. Terpenes are responsible for marijuana’s distinct smell.
How We Made This List?
There are many CBD oil products in the market and it is difficult to come up with the best CBD brand for anxiety. The brands included in this list were chosen based on:
- Brand reputation – Brands with high customer satisfaction mean brands that produce products that deliver what they promised. It also means that they deal with customers fairly and handle customer complaints better than other brands.
- Potency – CBD oils with high potencies mean high efficiency. They can provide more benefits in a short period of time. Brands that offer different levels of potency are also highly regarded since they can cater to a wider audience base and they give their customers the freedom to choose a dosage that suits them and their needs.
- Third-party testing – Brands that post complete third-party test results are preferred. This shows that the brand is transparent about their products and their manufacturing methods.
- Rewards programs – Companies have different rewards programs. A great rewards program is important especially for customers who plan on using CBD oil as anxiety treatment for a long time.
9 Best CBD Products For Anxiety
CBDistillery’s Full-Spectrum CBD Oil Tincture is the company’s most potent product. It is the most popular product in their lineup. The best-selling variant contains 1000mg of CBD per bottle and 33mg per 1ml serving.
If you haven’t tried CBD Oil before, CBDistillery also has a 500mg variant. They also have an even stronger 2500mg bottle. Due to its strength, the oil may taste too powerful for some but it is easy to get used to after a few uses.
The recommended serving is 1ml taken orally. Hold it under the tongue for around 15-20 seconds before swallowing. The effects vary per individual and you can adjust the dosage to suit your taste and needs.
This full-spectrum CBD oil tincture uses fractionated coconut oil (MCT) as its carrier oil. MCT is a great carrier oil because it is one of the best sources of lauric acid. Lauric acid has antibacterial and antimicrobial properties. On top of this, MCT helps deliver CBD straight into the human bloodstream. This means that you get to benefit from its anxiety-relieving properties almost immediately.
CBDistillery is well-known for its natural farming practices. They use non-GMO hemp oil to ensure that customers benefit from all-natural products. They engage the services of a third-party laboratory to test their products. This ensures that their products are of the highest quality and that their dosages are consistent. They also test for the presence of heavy metals, microbial, and toxins.
They have a loyalty program set in place for customers who frequently purchase their products. Customers can earn points per product purchase or by following CBDistillery’s social media accounts. These points are convertible to dollar amounts that you can use towards your next purchase.
#2. Lazarus Naturals
As its name suggests, Lazarus Naturals’ High Potency Full-Spectrum CBD Tincture is quite strong and is not recommended for those who are new to CBD oils. It contains 50mg of CBD per 1ml serving. The bottle is capped with a dropper that you can use to easily control dosage.
Lazarus Naturals uses all-natural products. Around 70 percent of their hemp comes from their own farm located in Oregon. They outsource the rest from farms certified by Oregon’s Department of Agriculture. This is an assurance to customers that they only use high-quality ingredients for all their products.
Lazarus Naturals has a partnership with Columbia Laboratories who tests all of their products. This ISO 17025-certified laboratory tests the potency of Lazarus Naturals’ products. They also ensure that all of the products are free from the presence of heavy metals, pesticides, and microorganisms.
Due to the organic nature of its ingredients, some customers complain that the High Potency Full-Spectrum CBD Tincture has a bitter taste. This bitter taste is due to the absence of artificial additives. If you need to get used to the natural taste of this tincture, they have one with a less potent dose.
If you are experiencing anxiety and having trouble sleeping, a dose of this tincture 1-2 hours prior to sleep might help you out. It can induce relaxation to help you sleep easily. If you need a stronger dosage, they also have a 3,000mg and a 6,000mg variant.
Lazarus Naturals has assistance programs to make their products more accessible. They offer a 60% discount for veterans, as well as people who suffer from a long-time disability. They extend the same discount for those who come from low-income households.
#3. +PlusCBD Oil
If you want to enjoy the benefits of CBD oil without dealing with its taste, PlusCBD Oil Drops might just be the one for you. It has a peppermint flavor that makes it taste refreshing. It comes in a 60ml bottle containing 500mg of CBD.
PlusCBD uses hemp that’s grown using natural agricultural methods. The hemp extract is then blended with extra virgin olive oil. PlusCBD also uses monk fruit and quillaja saponaria to give their products a sweeter taste.
This CBD oil product promises to be helpful in enhancing health in individuals who are already healthy. Their research also indicates that the use of full-spectrum hemp extract can help restore balance and homeostasis to the human body.
The use of PlusCBD’s Oil Drops helps provide individuals with a sense of calmness. This is ideal for people who need their full concentration for a task or project. For people who deal with anxiety disorders, the sense of calm that this product provides can help ease panic attacks or relieve stress.
If you want your CBD oil on the stronger side, PlusCBD has a CBD Oil Gold Drops. This Gold Formula promises higher levels of CBD. You can purchase oils with as much as 1500mg per 2oz bottle. They also come in three flavor profiles, unflavored, peppermint, and Goji Blueberry.
PlusCBD accepts retailers for their products and this is a great chance for CBD enthusiasts who would like to share their passion with other people while earning at the same time. You can sell their CBD pills for anxiety or their CBD isolate for anxiety. Just head on to their website and fill up their online form if you are interested in becoming a wholesaler.
#4. Nuleaf Naturals
Nuleaf Naturals’ Full Spectrum Hemp CBD Oil is one of the most top-rated CBD oils for anxiety. This product has more than 20,000 customer reviews on its website with an average rating of 4.9 stars out of a possible 5. Nuleaf Naturals is considered as one of the oldest in the industry. The company started in 2014 and its line of products and customer base has been growing steadily as the years pass by.
It is available in a 1800mg bottle. You can also order a less potent 300 or 900mg bottle. If you want a stronger CBD oil, you can also get this in a 3000 or 6000mg variant. This CBD oil doesn’t contain any flavorings. All that you will get is an earthy and slightly nutty flavor. It doesn’t contain any additives.
Nuleaf Naturals’ Hemp CBD Oil is ideal for those who want us hemp oil for anxiety but is unsure about the right dosage. The different dosages produced by Nuleaf Naturals allow customers to try different dosages until they find a dosage that works perfectly for them.
Nuleaf Naturals uses an advanced cultivation program that allows them to produce crops that are potent yet safe to use. They grow their organic hemp plants in Colorado. Their hemp plants benefit from the unspoiled rocky mountain water that allows them to reach their full potential.
Their advanced CO2 extraction procedures guarantee a stronger blend. This technique does not require the use of harsh chemical solvents and allows for a finished product that doesn’t contain harmful chemicals. This hemp oil product is also easy to get a hold of. Their products are available online not just for U.S. customers but for customers in more than 40 other countries. They also have more than a thousand physical stores and authorized dealers for those who want to get their hemp oil personally.
Nuleaf Naturals has assistance programs that provide their products to selected individuals at discounted prices. Veterans and active military personnel can avail of their assistance program. First responders, nurses, and medical providers are also eligible. It also covers the greatest number of individuals that include social workers, teachers, students, and non-profit groups.
Medterra might be a relative newcomer to the industry but is already making a name for itself. Their CBD Tincture is almost 100% pure CBD making it the most potent CBD oil for anxiety.
It has no additives and artificial flavorings. What you will get is a CBD tincture that tastes natural. This is a tincture that’s ideal for those who want to get all the benefits of CBD but cannot handle the taste associated with it.
If you like a few drops of CBD oil in your smoothie then this is an option that you might want to try. Since it is odorless and flavorless, it won’t change the taste of your smoothie. You can also take it sublingually without it leaving any unpleasant aftertaste in your mouth.
Medterra uses hemp grown in Kentucky. The soil and climate in Kentucky make it possible to grow hemp all year round. They also have rigorous guidelines strictly enforced by Kentucky’s Department of Agriculture. Medterra uses help that’s 100% organic and non-GMO. Another thing that sets Medterra’s tincture apart from others is the lack of THC. Other oils or tinctures contain traces of THC.
Medterra uses coconut-derived MCT oil as a carrier. This allows you to quickly absorb CBD into your bloodstream. It will help you relax and calm your nervous system in no time at all. This THC-free oil for anxiety comes in 3 strengths. You can get it in 500mg, 1,000mg, or 3,000mg. Customer reviews indicated that Medterra’s CBD tincture helps calm their nerves. Those with anxiety-related sleeping difficulties reported improvements in their sleeping patterns.
Medterra provides discounts for full-price orders made by U.S. military veterans and active military personnel. They also provide discounts for customers who have long-term disabilities.
CBDfx offers tinctures that are 100% vegan and non-GMO. They use MCT oil as a carrier to ensure quick absorption so you can enjoy the benefits of CBD in just a short period of time. Aside from CBD, their tincture contains fatty acids, amino acids, and vitamins that are beneficial to those who consume them.
Their most popular tincture is their medium-strength variant. It contains 100mg of CBD. This middle ground in potency makes it an ideal strength placing that sits right in the middle of the 500mg variant and the 1500mg variant. CBDfx’s unflavored oil tincture has almost no taste that will appeal to customers who have sensitive palates.
Although CBDfx does not claim any anxiety-relieving effects from any of its products, customer reviews in its website indicate varying degrees of success for customers with anxiety-related disorders. Customers claim that using CBDfx’s oil tincture helped them manage their anxiety and stress levels. Others claim that they felt more relaxed and slept better after using this product.
CBDfx offers third-party lab reports to assure customers that their products have a uniform dosage. These reports also indicate that CBDfx’s products are free from harmful chemicals and microorganisms.
The company also places emphasis on the fact that they adhere to sustainable and ethical sourcing and manufacturing processes. Their cruelty-free products were never tested on animals. They provide customers with a 30-day guarantee for their products. Customers are entitled to a full refund if they return qualified, unopened, and unused products within 30 days of the date of purchase.
CBDfx is a favorite for those looking for CBD Tincture Oil at favorable prices. CBDfx offers discounts for almost all of their products. You can also purchase bundles sold at even lower prices.
#7. Hemp Bombs
Hemp Bombs’ CBD Oil is an ideal oil for those who are just beginning their CBD journey. Their 300mg CBD Oil has a low concentration that a new CBD user can easily handle.
With its low potency, this is a CBD oil that may work well for those who experience general anxiety issues. This CBD tincture for anxiety may have soothing effects that can help reduce depression. It may also be effective as a mood enhancer.
The wide variety of flavors that Hemp Bombs offer also makes them popular for customers who are not too fond of the natural taste of CBD oil. They have six different flavors that you can choose from. You can get this CBD oil in Acai Berry, Watermelon, Peppermint, Chocolate Mint, Orange Creamsicle, and Natural Hemp.
Hemp Bombs is popular for people who use their CBD oil on their drinks or food. You can easily incorporate Hemp Bombs’ CBD oil in your daily routine. The different flavors allow customers the freedom to choose a flavor that will work well with their favorite food or drink.
The hemp that Hemp Bombs use in their products come from American farms. There is no indication though as to which particular state is the source of their products. Hemp Bombs partners with individuals who would like to become retailers. This is an exciting opportunity for those who want to take advantage of the growing market for CBD products. Hemp Bombs are also looking for distributors who can help deliver their products to previously untapped markets.
#8. Charlotte's Web
Charlotte’s Web is a name that CBD users easily recognize. They are one of the pioneers in the industry. They are certified by the U.S. Hemp Authority. They have a BBB accreditation and their average rating is an “A”.
Their most concentrated CBD drops for anxiety contain 60mg of CBD per ml. It uses full-spectrum hemp extract and is ideal for those who are already used to CBD oil and its effects.
If you have just started using CBD for anxiety issues, you can try Charlotte’s Web’s 17mg CBD Oil. It will allow your body to adjust to CBD and its effects. You can then move up to a more potent dose once you are sure that you can handle a more potent CBD oil.
Aside from CBD, their oil has terpenes, flavonoids, and phytocannabinoids that make it even healthier for customers. They designed their CBD oil to support a sense of calm so you can focus on any task at hand. It can also help you manage your stress so you can have a better sleeping pattern. If you don’t like the taste of hemp, you’re in for a treat since Charlotte’s Web’s hemp extract comes in three different flavors: Lemon Twist, Chocolate Mint, and Orange Blossom.
One of the things that customers notice with Charlotte’s Web’s hemp extract is the slight difference in the color of their oils. This is not surprising since Charlotte’s Web doesn’t use additives or dyes in their products.
Charlotte’s Web has a rewards program for frequent buyers. Customers accumulate points per purchase and they can convert the accumulated points to cash discounts on their next purchase. If you plan on using CBD oil as a long-term treatment aide for your anxiety disorder, sticking with Charlotte’s Web products can pay off in the long run.
#9. Koi CBD
Koi is a British company but holds operations in California. Their bestseller is their Koi Naturals Hemp Extract CBD Oil Tincture. This is a high-quality organic CBD for anxiety that you can buy in several strength levels. You can get them in 250mg, 500mg, 1000mg or 2000mg.
Koi uses organic coconut oil as a carrier to make it easy for you to absorb CBD into your bloodstream. The THC levels in their CBD oil are less than 0.001% which makes it almost undetectable.
If you are not fond of the taste of natural hemp, Koi’s CBD Oil comes in 5 other flavors that you can choose from. You can get it in Peppermint, Spearmint, Strawberry, Orange, or Lemon Lime. The wide variety of flavors make taking the oil sublingually an easy task. You can even add a couple of drops in your food or drink to help with your anxiety.
The raw materials that they use for their hemp products come from organic farms in southern Colorado. These farms have high elevations and benefit from the cold waters of the Rio Grande.
Koi uses an independent laboratory to test their hemp extracts. This ISO-accredited laboratory conducts multiple tests to ensure the high quality of all Koi products. The said tests also ensure that the products that Koi customers buy are free from contaminants like pesticides, solvents, microorganisms, and heavy metals. These test results are posted on Koi’s website and you can view them anytime.
If you plan to buy CBD oil for anxiety and you plan on doing it consistently, Koi’s rewards program is great news for you. Customers have several ways by which they can earn points. Aside from buying products, customers can also earn points when they post product reviews, refer new customers, or follow Koi’s social media accounts. These points are convertible to cash discounts so you can buy Koi products at even lower prices.
CBD Oil and Anxiety - How Does It Work?
These past few years, the relation between CBD oil and anxiety has been gaining attention. Experts are exploring the use of CBD for social anxiety and other anxiety disorders. A study published by The Permanente Journal showed that 79% of participants experienced reduced anxiety.
According to a 2019 Gallup poll, around 14% of Americans use CBD. A separate poll showed that 37% of CBD users use CBD as a form of treatment for their anxiety disorders. This underscores the importance of CBD products for Americans who are looking for natural products that can help treat their anxiety.
The use of CBD as a treatment for anxiety disorders stems from cannabidiol’s effects on the brain. CBD seems to have the ability to prevent the breakdown of a brain chemical responsible for pain, mood, and other mental functions.
When this the levels of this chemical increase in the bloodstream instead of breaking down psychotic symptoms associated with mental disorders get reduced. The said process also seems to reduce pain and anxiety.
It is important to note though that there is a need for more research to study the long-term effects of CBD on mental health.
What Research and Studies Say About CBD Oil for Anxiety
A study published in 2014 showed that CBD oil produced anti-anxiety and antidepressant effects in an animal model. According to an analysis conducted in 2015, CBD oil showed promise as a form of treatment for anxiety spectrum disorder. This includes social anxiety disorder, panic disorder, generalized anxiety disorder, and post-traumatic stress disorder.
According to the Journal of Psychopharmacology, a study conducted in 2010 investigated the effects of CBD on patients with a generalized social anxiety disorder. The subjects received either an oral dose of 400mg of CBD or a placebo. Those who received CBD showed significantly decreased subjective anxiety compared to those who received the placebo.
In 2019, the Japanese studied the effects of CBD on 40 teenagers with a social anxiety disorder. The subjects were 18 to 19 years of age and exhibit avoidant personality disorder. During a period of 4 weeks, half of the subjects received a daily dose of cannabis oil with 300mg of CBD. The other half received a daily dose of a placebo made with olive oil. Post Intervention assessment showed that the subjects who received CBD showed lower levels of anxiety. The assessment also revealed that the half that received the placebo did not show any change in anxiety levels.
CBD Dosage for Anxiety: How Much Should You Take?
If you are interested in using CBD oil as a treatment for anxiety, the next logical question is how much should you take?
As with any other medicine, there is no exact CBD dosage (mg) for anxiety. The dosage that works perfectly for others may not work or maybe too much for you.
The first and most prudent thing to do is to consult your doctor. Your doctor knows your medical history and other underlying medical conditions and these can help your doctor determine a starting dosage that will work best for you.
Following the Stepwise Dosing procedure is a safe way of determining a dosage that works. Starting at a minimal baseline dosage can help you arrive at an effective dosage without fear of using a dosage that is too potent.
Start with a small dose of around 5mg taken twice or thrice a day. Use this baseline dosage for an entire week. During this stage, it is important to take note of the effects of CBD on your body. At the end of 7 days, if you feel that you are not getting the desired results or benefits, you can start increasing your dosage. Increase your dosage by 1-2mg every 3 days. Do this until you reach a dosage that delivers your desired effects.
The incremental increase in dosage will help you ensure that you arrive at the correct dosage without going over. It also helps your body get used to the increasing dosage without getting overwhelmed.
What Are The Side Effects of CBD Oil?
Clinical research shows that CBD oil may cause some minor side effects. Although these are just minor side effects, it is still important to take note of them before using a form of CBD treatment for anxiety.
Common side effects include:
- Dry mouth
- Changes in appetite
There is a possibility that CBD oil may increase liver enzymes. Cannabinoids inhibit the activity of a family of liver enzymes called cytochrome P450. These are enzymes that metabolize some of the drugs that we consume. Certain doses of CBD can temporarily deactivate cytochrome P450.
You should consult your doctor prior to taking CBD oil if you are taking a medication with a grapefruit consumption warning. Taking CBD oil may prevent the effectiveness of the said medication.
Those who are pregnant or breastfeeding should avoid using CBD oil. In 2018, the American Academy of Pediatrics issued a warning about the potential risks that CBD may have to a baby’s development. CBD has the capacity to pass through the barrier of the placenta and into the unborn child. Consult your doctor about the possibility of using topical CBD for anxiety as an alternative.
CBD has the potential to help patients suffering from Parkinson’s Disease. However, there were reports of an increase in tremors caused by very high doses of CBD. Decreasing the dosage of CBD can help eliminate this increase in tremors.
What Is The Best Form of CBD Oil for Anxiety?
The most popular forms of CBD oil are oils and tinctures. CBD oil is the most potent form of CBD. It is also the most expensive. On top of cannabinoids, CBD oil also contains nutrients, fatty acids, proteins, and essential vitamins.
CBD oils use carrier oils. The carrier oil helps dilute CBD. This helps the human body easily absorb CBD. Common carrier oils include hemp seed oil, coconut oil, MCT oil, vegetable glycerin base, sunflower oil, avocado oil, and extra virgin olive oil.
On the other hand, CBD tincture uses CBD suspended under 60 to 70% distilled alcohol. Tinctures are often hemp extract mixed with alcohol, glycerin, or peppermint/cinnamon oil. CBD tinctures are not as potent as CBD oils. However, CBD tinctures have long shelf lives. The presence of alcohol acts as a preservative that enhances the life of CBD.
So, is CBD oil better compared to CBD oil tincture? It depends on your end goal. The potency of CBD oil makes it ideal for those who want to get the best results in as little a dose as possible. However, one should use high-dosage CBD oil with caution. Be sure that your body can handle the effects of high dose CBD. This is where Stepwise Dosing comes into play. Reaching a high dosage slowly can help prepare your body and prevent side effects.
CBD tincture is recommended for those who want immediate relief. The presence of alcohol in tinctures gives them higher bioavailability. Bioavailability is the portion of CBD, or any other drug or substance, that enters the bloodstream. This means that your body absorbs more CBD and it will take a shorter time for you to feel its effects.
How to Use CBD Oil for Anxiety
There are two popular ways of taking CBD for depression or anxiety when purchased in oil or tincture form. The most common way is to take it sublingually.
In this method, you drop CBD oil or tincture under your tongue. Hold it for at least 20-30 seconds before swallowing. You can also swish the oil or tincture around your mouth before swallowing. This is the quickest way to feel the effects of CBD. CBD gets absorbed by the blood vessels under the tongue. This allows the CBD to bypass the digestive system. This method also means that less CBD gets wasted.
Although this is a highly effective method, users who have sensitive palates may not like this method. The taste of CBD is an acquired taste and not everyone takes a liking to it. If you dislike the natural taste of CBD, there are flavored oils or tinctures that you can try. The added flavoring can mask the taste of CBD and make it easier for the taste.
Another way of using CBD oil is by adding it to your food or drink. You can use it as an additive to your recipe. You can even add a few drops into your cookie, cupcake, or bread dough before baking. You can also add a few drops on your coffee, smoothie, tea, chocolate, or any other beverage. The downside with this method is it requires CBD to pass through the digestive system. This means that some potency will be lost in the process.
How to Buy CBD Oil for Anxiety
Buying CBD oil is no longer as difficult as it was a few years ago. There are now many companies manufacturing CBD oil and other CBD products. The legalization of CBD products also paved the way for more retailers and distributors.
CBD products are now available online and in physical stores. If you don’t have a physical brick and mortar store near you, you can order CBD oil online. Some brands offer free shipping when you purchase a minimum dollar amount of products. Just make sure that you live in a state that allows the shipping of CBD products.
3 Helpful Tips for Choosing the Best CBD Treatment for Anxiety
Just like any other product, not all CBD oils are equal in quality. It is up to you to choose the type of oil and method to use that will provide you with the best results.
- Consult your doctor
Your doctor is the best resource when it comes to choosing a CBD-based treatment for your anxiety. Your doctor knows what type of anxiety disorder you have. Your doctor can also perform a complete medical checkup to ensure that you don’t have any other comorbidities which may prevent CBD from working for you.
Your doctor can also suggest a starting dose that is safe for you based on your physical and mental well-being.
- Verify the growing standards and extraction method
Think of it as a food that you will consume. As much as possible, you want to know if the CBD you will bring into your system is all-natural and organic. As much as possible, avoid products that use pesticides since it can leave residues that may be harmful to you. Poor growing standards can also mean the use of fertilizers and other harmful chemicals.
Manufacturers can use several methods to extract CBD oil. The most common means are through CO2 extraction, solvent extraction, and steam distillation. CO2 Extraction is a modern and preferred method of extraction. It yields the highest concentration of CBD. It also helps prevent harmful residue.
- Look for Third-Party Testing Results
Third-party testing is a great way to ensure that a company adheres to manufacturing standards. These tests are in place to make sure that all products have uniform dosages. They will also show if the CBD oil that you are about to take contains less than 0.03% THC. The said tests indicate if the product contains traces of heavy metals, toxins, or chemicals.
Most CBD companies post third-party test results on their website. If your preferred brand doesn’t post third-party test results, you might want to think about switching to another brand.
The study of the relationship between cannabidiol and anti-anxiety medication is still in its infancy. Although several studies suggest that CBD oils that contain lab-tested CBD dose for anxiety might help, these studies are still inconclusive.
Studies still cannot provide information on the benefits of using CBD oil as a long-term treatment for anxiety disorders.
If you are considering the use of CBD oil to ease anxiety, depression, or as a sleeping aid, consider the recommendations on this list but still do your own research. Share your plans to your doctor to ensure that taking CBD will not have any adverse effect on any medication or supplement that you are using.